Profesor Asistente
Programa Genética Humana, ICBM
Facultad de Medicina, Universidad de Chile
Líneas de Investigación.
Genómica y Bioinformática de Caracteres Complejos
Publicaciones
Verdugo RA, Zeller T, Rotival M, Wild PS, Münzel T, Lackner KJ, Weidmann H, Ninio E,Trégouët DA, Cambien F, Blankenberg S, Tiret L. 2013. Graphical Modeling of Gene Expression in Monocytes Suggests. Molecular Mechanisms Explaining Increased Atherosclerosis in Smokers. PLoS ONE 8(1): e50888. doi:10.1371/journal.pone.0050888. ISI 3.534 ISSN 0718-560X
Leduc MS, Blair RH, Verdugo RA, Tsaih SW, Walsh K, Churchill GA, Paigen B. 2012. Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ x SM/J intercross. J Lipid Res. 53:1163-1175. ISI 4.73 ISSN 0022-2275
Aylor DL, W Valdar, W. Foulds-Mathes, RJ Buus, RA Verdugo, RS Baric, MT Ferris et al.+32 autores..D Pomp, D Threadgill, F Pardo,Manuel de Villena, G A. Churchill. 2011. Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res. 21: 1213- 1222. ISI. En negrita: igual contribución a este trabajo. ISI 13.852 ISSN 1088-9051
Leduc MS, Hageman RS, Verdugo RA, Tsaih SW, Walsk K, Churchill GA and Paigen B. 2011. Integration QTL and bioinformatic tools to identify candidate genes for tryglicerids in mice J. Lipid Res. 52: 1672-1682. ISI 4.73 ISSN 0022-2275
Leme AS, Berndt A, Williams LK, Tsaih S, Szatkiewicz JP, Verdugo RA, Paigen B, Shapiro SD. 2010. A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Molecular Genetics and Genomics 283: 317- 316 ISI 2.831 ISSN 1617-4615
Leduc MS, Hageman RS, Meng Q, Verdugo RA, Tsaih S, Churchil GA, Paigen B, Yuan R. 2010. Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. Aging Cell 9: 823–836 ISI 5.939 ISSN 1474-9726
Verdugo RA, Farber CR, Warden CH, Medrano JF. 2010. Serious limitations of the QTL/microarray approach for QTL gene discovery. BMC Biol. 2010 Jul 12; 8:96. doi: 10.1186/1741-7007-8-96. ISI 7.431 ISSN 1752-0509
Casellas J, Farber CR, Verdugo RA, Medrano JF. 2010. Segregation analysis of a sex ratio distortion locus in congenic mice. J Hered. 101: 351- 359. ISI 1.969.ISSN 1465-7333
Verdugo RA, Deschepper CF, Muñoz G, Pomp D, Churchill GA. 2009. Importance of randomization in microarray experimental designs with Illumina platforms. Nucleic Acids Res. 37: 5610-5618. ISI 8.808 ISSN 1362-4962
Llamas B, Verdugo RA, Churchill GA, Deschepper CF. 2009. Chromosome Y variants from different inbred mouse strains are linked to differences in the morphologic and molecular responses of cardiac cells to postpubertal testosterone. BMC Genomics. 2009 Apr 7;10:150. doi: 10.1186/1471-2164-10-150 (Primera autoría compartida) ISI 4.4 ISSN 1471-2105
Farber CR, Chitwood J, Lee SN, Verdugo RA, Islas-Trejo A, Rincon G, Lindberg I, Medrano JF. 2008. Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice. BMC Genet. 2008 Apr 25;9:34. doi: 10.1186/1471-2156-9-34.ISI 2.672 ISSN 1471-2156
Verdugo RA and JF Medrano. 2006. Comparison of gene coverage of mouse oligonucleotide microarray platforms. BMC Genomics 2006, 7:58 doi:10.1186/1471-2164-7-58 ISI 4.4 ISSN 1471-2105